Discovery of 1-(4-cyanopyrimidin-2-yl)-1H-pyrazole-4-carboxylic acids as potent xanthine oxidase inhibitors via molecular cleavage and reassembly of allopurinol as a key strategy

Bioorganic Chemistry 2026

View at publisher

Authors: Han Wang, Jinxin Li, Tong Liu, Qingbo Song, Qi Li, Qing Mao, Xuefeng Fu, Xiwen Dai, Jiahui Wang, Xiang Shi, Bing Zhang, Yue Zhu

+1 more

Tingjian Zhang

DOI: 10.1016/j.bioorg.2026.109481

Cited by: 1

References: 45

Fields of Study & Subjects

Gout Hyperuricemia Uric Acid Thyroid Disorders and Treatments Inflammasome and immune disorders

References 45