Reconnecting new tetrahydrobenzothieno-4-pyrimidine amides as potent PIM-1 kinase inhibitors via an integrated ligand, machine learning model and structure based scaffold hopping: In vitro anti-tumor investigations

Bioorganic Chemistry 2026

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Authors: Vinayak Walhekar, Amol Muthal, Mahesh M. Ghaisas, Nagarjuna Rao Mamidipalli, Raghavendra Kulkarni, Raghavendra Kulkarni, Ravindra Kulkarni, Ravindra Kulkarni
DOI: 10.1016/j.bioorg.2026.109487
Cited by: 2
References: 28

Fields of Study & Subjects

Cancer Mechanisms and Therapy Mechanisms of cancer metastasis Synthesis and biological activity

Publication details

Journal / source
Bioorganic Chemistry
Publisher
Elsevier BV
Volume
170
Pages
109487–109487
Publication date
10 January 2026
Language
EN