Design, synthesis and biological activity of dimeric pyrazolo[3,4-d]pyrimidin-4-one derivatives as selective SHP2 orthosteric inhibitors

Bioorganic Chemistry 2026

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Authors: Yi Wang, Xiaoyu Shao, Meijing Wang, Z. Li, Yang Sun, Xiangbao Meng

DOI: 10.1016/j.bioorg.2026.109573

Cited by: 0

References: 37

Fields of Study & Subjects

Protein Tyrosine Phosphatases Synthesis and biological activity Protein Kinase Regulation and GTPase Signaling

References 37