Discovery of new non-macrocyclic TRK inhibitors based on conformational flexibility and scaffold hopping to overcome clinical acquired resistance

Bioorganic Chemistry 2026

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Authors: Zhong-Rui Liu, Zi-Long Li, Hong-Chuang Xu, Xiu-Qin Yang, Neng-Fang She, Long-Can Mei, Wei Min Huang

DOI: 10.1016/j.bioorg.2026.109603

Cited by: 0

References: 47

Fields of Study & Subjects

Computational Drug Discovery Methods Lung Cancer Treatments and Mutations Synthesis and biological activity

References 47