Discovery and optimization of 1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide derivatives as USP1 inhibitors for BRCA1-mutant cancer treatment

Bioorganic Chemistry 2026

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Authors: Tuotuo Zhao, Congwei Chen, Yuxiang An, Yuting Xu, Yong Guo, Shanyan Yao, Baobao Zhou, Yi Chen, Wenhu Duan, Zhiyu Guan, Wei Tang, Hefeng Zhang
DOI: 10.1016/j.bioorg.2026.109820
Cited by: 1
References: 32

Fields of Study & Subjects

PARP inhibition in cancer therapy Ubiquitin and proteasome pathways Biochemical and Molecular Research

Publication details

Journal / source
Bioorganic Chemistry
Publisher
Elsevier BV
Volume
175
Pages
109820–109820
Publication date
3 April 2026
Language
EN