Discovery of a potent and orally available SOS1 inhibitor with antitumor efficacy in KRAS-mutant colorectal cancers

Bioorganic Chemistry 2026

View at publisher
Authors: Xingchen Liu, Yuzhou Xiao, Lingfeng Tang, Yanmei Zhou, Jinhua Zhao, Jiao Zou, Yue Zhou, Yaxin Teng, Xinyu Fan, Jiahao Qiu, Jing Xu, Zhiqiang Qiu
+12 more Kun Gou, Haoyue Luo, Yanyan Ren, Xiaodan Pan, Jialing Song, Wenjing Xu, Ping Gao, Bo Ren, Xia Zhou, Xiaobo Cen, Youfu Luo, Yinglan Zhao
DOI: 10.1016/j.bioorg.2026.109823
Cited by: 1
References: 50

Fields of Study & Subjects

Protein Kinase Regulation and GTPase Signaling PI3K/AKT/mTOR signaling in cancer Cytokine Signaling Pathways and Interactions

Publication details

Journal / source
Bioorganic Chemistry
Publisher
Elsevier BV
Volume
175
Pages
109823–109823
Publication date
3 April 2026
Language
EN