New mitochondrial KV1.3 conjugates are potent and specific inducers of apoptosis in cancer models

Biomedicine & Pharmacotherapy 2026 Open access

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Authors: Špela Gubič, Marzia Fois, Xiaoyi Shi, Ivan Džajić, Daniela Secci, Katja Kološa, Alja Štern, Joshua A. Nasburg, Hai Minh Nguyen, Veronica Carpanese, Gayathri Viswanathan, Vanessa Checchetto
+13 more Maša Omerzel, Tim Božič, Boštjan Markelc, Tanja Jesenko, Maja Cemazar, Ildiko Szabo, Heike Wulff, Bojana Žegura, Tina Kosjek, Andrej Emanuel Cotman, Tihomir Tomašič, Luis A. Pardo, Lucija Peterlin Mašič
DOI: 10.1016/j.biopha.2026.118996
Cited by: 1
References: 45

Abstract

1.3 inhibitors with enhanced solubility compared to psoralen-based analogues. The unique mechanism of action, characterized by rapid depolarization and moderate ROS dependence, underscores their potential as selective anticancer agents. These findings warrant further investigation into in vivo efficacy and potential synergy with existing therapies.

Fields of Study & Subjects

Ion channel regulation and function Mitochondrial Function and Pathology Nicotinic Acetylcholine Receptors Study

Publication details

Journal / source
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Volume
195
Pages
118996–118996
Publication date
15 January 2026
Language
EN