The multifaceted antineoplastic effects of arenobufagin against human cancers

Biomedicine & Pharmacotherapy 2026 Open access

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Authors: Gulafsha Siddiqui, Aditya Bhushan Pant, Chakrabhavi Dhananjaya Mohan
DOI: 10.1016/j.biopha.2026.119062
Cited by: 1
References: 83

Abstract

Toad-based therapies (Chansu) are a part of traditional Chinese medicine (TCM) in which toad venom is used for the treatment of cancers. Toad venom is a complex mixture of steroid-based compounds called bufadienolides, which have good anticancer potential. Arenobufagin is a toad venom-derived bufadienolide that has been endowed with strong antitumor activity. Most of the studies have demonstrated that arenobufagin shows potent cytotoxicity in cell-based assay systems (IC 50 value:

Fields of Study & Subjects

Ion Transport and Channel Regulation Ion channel regulation and function Phytochemical Studies and Bioactivities

Publication details

Journal / source
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Volume
195
Pages
119062–119062
Publication date
26 January 2026
Language
EN