A case report: intravenous provocation testing clears rocuronium after sugammadex-rocuronium complex-induced anaphylaxis

BJA Open 2026 Open access

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Authors: Myrthe de Haas, Mark Vincent Koning, Matthias H. Busch, Tessa Langeveld
DOI: 10.1016/j.bjao.2026.100541
Cited by: 1
References: 8

Abstract

Perioperative anaphylaxis is a life-threatening condition, of which the neuromuscular blocking agents (NMBAs) are the causative agent in 40–60% of perioperative immediate hypersensitivity reactions, especially rocuronium.1 Sugammadex is the reversal agent of rocuronium, which acts by forming a high-affinity complex (S-R-Cx) with rocuronium in plasma and reduces the amount of available rocuronium. Hypersensitivity reactions to sugammadex have been reported, but its determination as a causative agent may be difficult, as not only the sugammadex, but also S-R-Cx may be the culprit.

Fields of Study & Subjects

Anesthesia and Sedative Agents Food Allergy and Anaphylaxis Research Migraine and Headache Studies

Publication details

Journal / source
BJA Open
Publisher
Elsevier BV
Volume
17
Pages
100541–100541
Publication date
27 February 2026
Language
EN