Non-surgical management of mandibular central giant cell granuloma using denosumab
Abstract
The typical management of central giant cell granuloma (CGCG) of the jaws involves curettage or resection; however, in selected cases, medical therapies such as denosumab have emerged as potential alternatives. We present the case of a 22-year-old patient who presented with a right mandibular expansile lesion. Imaging and biopsy confirmed mandibular CGCG. The patient was managed non-surgically with denosumab, and follow-up imaging demonstrated lesion stabilisation and radiographic maturation. Denosumab may represent an alternative to surgery when operative management carries significant morbidity.
Fields of Study & Subjects
Bone Tumor Diagnosis and Treatments
Oral and Maxillofacial Pathology
Head and Neck Surgical Oncology
Publication details
- Journal / source
- British Journal of Oral and Maxillofacial Surgery
- Publisher
- Elsevier BV
- Volume
- 64
- Issue
- 6
- Pages
- 502–504
- Publication date
- 5 May 2026
- Language
- EN