Conformational restriction of hinge carboxamide leading to potent lactam-based PKMYT1 inhibitors

Bioorganic & Medicinal Chemistry 2026

View at publisher

Authors: Yazhou Wang, Xiaomin Wang, Chao Wang, Tingting Liu, Xin Cai, Man Zhang, Alex Aliper, Feng Ren, Alex Zhavoronkov, Xiao Ding

DOI: 10.1016/j.bmc.2026.118582

Cited by: 4

References: 48

Fields of Study & Subjects

PI3K/AKT/mTOR signaling in cancer Protein Kinase Regulation and GTPase Signaling Histone Deacetylase Inhibitors Research

References 48