Experimentally informed, quantitative photocycle model of the light-gated potassium channel WiChR

Biophysical Journal 2026 Open access

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Authors: Sophia Ohnemus, Linda Tillert, Roberta De Zio, Raluca-Andreea Tifrea, Andries Napo Leemisa, Simon Beyer, Peter Köhl, Viviane Timmermann, Franziska Schneider-Warme, Johannes Vierock
DOI: 10.1016/j.bpj.2026.01.056
Cited by: 3
References: 57

Abstract

concentration during extended illumination. These changes are promoted by the large photocurrent amplitudes observed in WiChR-expressing cells and differ substantially among individual cells and across cell types, underlining the importance of the optogenetically targeted host system. Our model presents a framework for assessing and predicting WiChR photoresponses and will be useful for guiding the design of optimized stimulation protocols for future application of WiChR and other KCRs.

Fields of Study & Subjects

Photoreceptor and optogenetics research Plant and Biological Electrophysiology Studies Light effects on plants

Publication details

Journal / source
Biophysical Journal
Publisher
Elsevier BV
Volume
125
Issue
10
Pages
2363–2379
Publication date
6 February 2026
Language
EN