Channel gating in bacteriorhodopsin-like channelrhodopsins with contrasting K+ and Na+ selectivity

Biophysical Journal 2026 Open access

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Authors: Oleg A. Sineshchekov, Elena G. Govorunova, Hai Li, Yumei Wang, John L. Spudich
DOI: 10.1016/j.bpj.2026.02.004
Cited by: 1
References: 37

Abstract

-selective variants, but was delayed in HcKCR1 and its mutants. Our results contribute to a deeper mechanistic understanding of light-gated cation conductance in BCCRs, facilitating the further development of optogenetic tools.

Fields of Study & Subjects

Photoreceptor and optogenetics research Neuroscience and Neuropharmacology Research Plant and Biological Electrophysiology Studies

Publication details

Journal / source
Biophysical Journal
Publisher
Elsevier BV
Volume
125
Issue
10
Pages
2380–2390
Publication date
10 February 2026
Language
EN