Executive Function in Obsessive-Compulsive Disorder: A Worldwide Mega-Analysis of Task-Based Functional Neuroimaging Data of the ENIGMA-OCD Consortium

BACKGROUND: Obsessive-compulsive disorder (OCD) is associated with impaired executive function and altered activity in associated neural circuits, contributing to reduced goal-directed behavior. To investigate neural activation during executive function, we conducted a mega-analysis in the ENIGMA-OCD consortium pooling individual participant data from 475 individuals with OCD and 345 healthy control participants across 15 functional magnetic resonance imaging (fMRI) tasks collected worldwide. METHODS: Individual participant data were uniformly processed using HALFpipe to construct voxelwise statistical images of executive processing and task load contrasts. Parameter estimates extracted from regions of interest were entered into multilevel Bayesian models to examine regional and whole-brain effects of diagnosis and, within OCD, the influence of medication status, symptom severity, and age of onset on task activation. RESULTS: We observed a robust task activation pattern across individuals with OCD and control participants in executive processing regions across tasks. Relative to control participants, individuals with OCD showed moderate to very strong evidence of weaker activation of the dorsolateral prefrontal cortex, precuneus, frontal eye fields, and inferior parietal lobule during executive function (all positive posterior probabilities