Risk Stratified Breast Cancer Screening: Early Outcomes and Psychological Impact from PRSONAL – a Randomized Clinical Trial

The Breast 2026 Open access

Read full text
Authors: Line Hjøllund Pedersen, Janne Bigaard, Ilse Vejborg, Pia R. Kamstrup, Berit Andersen, Xin Yang, Lorenzo Ficorella, Joe Dennis, Antonis C. Antoniou, Henrik Flyger, S. Bojesen
DOI: 10.1016/j.breast.2026.104743
Cited by: 3
References: 24

Abstract

PURPOSE: Risk-stratified screening for breast cancer might improve benefit-to-harm ratio, however, psychological consequences of risk communication and low-risk women's acceptance of de-escalated screening are unclear. PATIENTS AND METHODS: We carried out a randomized clinical trial allocating women aged 50-67 years attending their routine biennial screening mammography 1:1 to a control and intervention group. Women in the control group continued the standard program without risk stratification. Women in the intervention group had their 10-year breast cancer risk assessed using the comprehensive CanRisk model. Around day 90, risk was automatically communicated as low (

Fields of Study & Subjects

Global Cancer Incidence and Screening BRCA gene mutations in cancer Breast Cancer Treatment Studies

Publication details

Journal / source
The Breast
Publisher
Elsevier BV
Volume
86
Pages
104743–104743
Publication date
24 February 2026
Language
EN