Risk of low-frequency ultrasound stimulation: Response to “Brain injury during focused ultrasound neuromodulation for substance use disorder”

Brain stimulation 2026 Open access

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Authors: Andrew A.E.D. Bishay, Samantha Schafer, Alexander Bystritsky, William J. Tyler, Martin M. Monti, Jan Kubanek, Joseph L. Sanguinetti, Norman M. Spivak
DOI: 10.1016/j.brs.2026.103091
Cited by: 2
References: 11

Abstract

We are writing to offer our perspective on the correspondence by Rezai et al.[1], disclosing a serious adverse event (SAE) incurred by low-intensity transcranial focused ultrasound stimulation (tFUS). Like others, we recognize the limitation in only providing the 90 W free-field power output in the initial report and commend the tFUS community for successfully pushing for the release of more detailed sonication parameterization, including mechanical index (MI) and intensity, to compare to the published record of safety of low-intensity tFUS[2].

Fields of Study & Subjects

Ultrasound and Hyperthermia Applications Vagus Nerve Stimulation Research Ultrasound and Cavitation Phenomena

Publication details

Journal / source
Brain stimulation
Publisher
Elsevier BV
Volume
19
Issue
3
Pages
103091–103091
Publication date
29 March 2026
Language
EN