Circuit-informed targeting for psychiatric comorbidity in depression: An accelerated TMS pilot study

Brain stimulation 2026 Open access

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Authors: Lauren Sanderson, Anjali Chandra, Emma Jones, Leanna Bomer, Natalie Hall, Marina R. Kare, David Lawson, Nicole Chiulli, Ryan D. Webler, Sheena R. Baratono, Irene Gonsalvez, Stanley Lyndon
+3 more Michael D. Fox, Shan H. Siddiqi, Joseph J. Taylor
DOI: 10.1016/j.brs.2026.103106
Cited by: 1
References: 7

Abstract

Psychiatric comorbidity is common and associated with poorer outcomes(1). Despite shared circuitry across disorders(2), transcranial magnetic stimulation (TMS) trials typically target a single brain circuit and exclude individuals with comorbidities(3). For example, TMS for depression often targets a circuit defined by anticorrelation between the left dorsolateral prefrontal cortex (DLPFC) and the subgenual cingulate. This targeting strategy has been associated with antidepressant outcomes. However, its predictive value may be reduced in individuals with psychiatric comorbidities(4).

Fields of Study & Subjects

Treatment of Major Depression Neurotransmitter Receptor Influence on Behavior Mental Health Treatment and Access

Publication details

Journal / source
Brain stimulation
Publisher
Elsevier BV
Volume
19
Issue
3
Pages
103106–103106
Publication date
21 April 2026
Language
EN