Personalized high-dose accelerated intermittent theta-burst stimulation improves cognitive function in mild Alzheimer's disease: A randomized sham-controlled trial

Brain stimulation 2026 Open access

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Authors: Na Xu, Yi Xing, Aonan Li, Shuaicheng Liu, Jing Gao, Xinyu Liu, Wuxiang Xie, Ning Guo, Yue Chen, Xiaoyue Sun, Jilin Wu, Weijun Gong
+3 more Danhong Wang, Yi Tang, Hesheng Liu
DOI: 10.1016/j.brs.2026.103142
Cited by: 1
References: 9

Abstract

Alzheimer’s disease (AD) is characterized by dysfunction of large-scale brain networks, particularly the default mode network (DMN) and working memory network (WMN), with pathology, atrophy, and disconnection in these networks closely associated with cognitive decline [1]. Disease progression has been proposed to involve cascading dysfunction across these networks [2], with posterior DMN regions affected early and prefrontal DMN and WMN regions increasingly involved over time. Given their pivotal roles, these hub regions may represent promising targets for circuit-based AD therapies.

Fields of Study & Subjects

Transcranial Magnetic Stimulation Studies Vagus Nerve Stimulation Research Neurological disorders and treatments

Publication details

Journal / source
Brain stimulation
Publisher
Elsevier BV
Volume
19
Issue
4
Pages
103142–103142
Publication date
13 June 2026
Language
EN