Nonbacterial Thrombotic Endocarditis and Mechanical Valve Thrombosis in a Patient with Antiphospholipid Syndrome

CASE 2026 Open access

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Authors: Fox Bravo, Christy Lougheed, Jeffery Tran, Kwan S. Lee, Toshinobu Kazui, Arka Chatterjee, Tushar Acharya
DOI: 10.1016/j.case.2025.12.002
Cited by: 0
References: 11

Abstract

We present a case of antiphospholipid syndrome– (APS-) associated nonbacterial thrombotic endocarditis (NBTE) causing severe mitral stenosis (MS) requiring surgical valve replacement, followed by mechanical valve thrombosis (MVT) successfully treated with fibrinolytic therapy. This case brings forth multiple APS-associated thrombotic complications including pulmonary embolism (PE), stroke, NBTE-induced MS (which is exceedingly rare), and MVT, thus stressing the difficulties in managing thrombosis risk despite oral anticoagulation therapy.

Fields of Study & Subjects

Systemic Lupus Erythematosus Research Infective Endocarditis Diagnosis and Management Cardiac tumors and thrombi

Publication details

Journal / source
CASE
Volume
10
Issue
3
Pages
107–114
Publication date
9 February 2026
Language
EN