Armored macrophage-targeted CAR-T cells reset and reprogram the tumor microenvironment and control metastatic cancer growth

Cancer Cell 2026 Open access

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Authors: Jaime Mateus-Tique, Ashwitha Lakshmi, Bhavya Singh, Rhea Iyer, Alfonso R. Sánchez-Paulete, Chiara Falcomatà, Matthew Lin, Gvantsa Pantsulaia, Alexander Tepper, Trung Nguyen, Angelo Amabile, Gürkan Mollaoglu
+9 more Luisanna Pia, Divya Chhamalwan, Jessica Le Berichel, Hunter Potak, Marco Colonna, Alessia Baccarini, Joshua Brody, Miriam Merad, Brian D. Brown
DOI: 10.1016/j.ccell.2025.12.021
Cited by: 19
References: 75

Fields of Study & Subjects

CAR-T cell therapy research Immune cells in cancer Cancer Immunotherapy and Biomarkers

Publication details

Journal / source
Cancer Cell
Publisher
Elsevier BV
Volume
44
Issue
3
Pages
534–550.e11
Publication date
22 January 2026
Language
EN