Early intervention versus treatment as usual for adolescents with first-episode psychosis: Protocol for the randomized OPUS YOUNG trial

Contemporary Clinical Trials 2026 Open access

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Authors: Mathilde S. Madsen, Marianne Melau, Naja Kirstine Andersen, Caroline Friis Nielsen, Natascha Larsen, Thomas Lind Andersen, Merete Nordentoft, Jens Richardt M. Jepsen, Anne AE Thorup, Pia Jeppesen, Birgitte Fagerlund, Martin Køster Rimvall
+9 more Patrick D. McGorry, Swaran Singh, Ditte Lammers Vernal, Lene Halling Hastrup, Lis Raabæk Olsen, Jacob Rydkjær, Christoph Ulrich Correll, Robin Christensen, Anne Katrine Pagsberg
DOI: 10.1016/j.cct.2026.108253
Cited by: 0
References: 66

Abstract

BACKGROUND: The prognosis for early onset psychosis (EOP) is poor for a broad range of outcomes. Early intervention services (EIS) have proven beneficial for adult-onset first-episode psychosis, but no randomized trials have investigated EIS in samples of patients aged

Fields of Study & Subjects

Schizophrenia research and treatment Psychiatric care and mental health services Psychotherapy Techniques and Applications

Publication details

Journal / source
Contemporary Clinical Trials
Volume
162
Pages
108253–108253
Publication date
5 February 2026
Language
EN