Reticulocalbin1-mediated regulation of calcium homeostasis in naïve T lymphoncytes

Cell Calcium 2026 Open access

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Authors: Takeru Kobayashi, Wooseok Seo, Norihisa Ichimura, Yusuke Urata, Hideharu Hibi, Hiroyoshi Nishikawa
DOI: 10.1016/j.ceca.2026.103121
Cited by: 0
References: 18

Abstract

T cells. In contrast, stimulus-induced calcium responses, including ER calcium release, extracellular calcium entry, and TCR-dependent calcium flux, were preserved in both genotypes. Collectively, our results suggest that RCN1 contributes to the fine-tuning of ER-associated calcium handling in naïve (non-activated) T cells, thereby modulating basal cytosolic calcium levels and supporting efficient thymic CD8⁺ T cell development.

Fields of Study & Subjects

Ion Channels and Receptors Ion channel regulation and function Calcium signaling and nucleotide metabolism

Publication details

Journal / source
Cell Calcium
Volume
134
Pages
103121–103121
Publication date
16 January 2026
Language
EN