Human genetics guides the discovery of CARD9 inhibitors with anti-inflammatory activity

Cell 2026 Open access

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Authors: Jason S. Rush, Joshua Wertheimer, Steven D. Goldberg, D.D. Raymond, Mateusz Szuchnicki, Andrew J. Baltus, Jeff Branson, Christopher F. Stratton, Aaron Patrick, Ruth Steele, Suraj Adhikary, Amanda Del Rosario
+15 more Annie X. Liu, Noah J. Gomersall, Michael T. Chung, Matthew J. Ranaghan, Xiebin Gu, Marta Brandt, Zhifang Cao, Adrian M. Bebenek, Blayne A. Oliver, Kasper Hoebe, Lawrence M. Szewczuk, Jennifer D. Venable, Daniel B. Graham, Jennifer E. Towne, Ramnik J. Xavier
DOI: 10.1016/j.cell.2025.12.013
Cited by: 6
References: 44

Fields of Study & Subjects

NF-κB Signaling Pathways Inflammatory Bowel Disease Immune Response and Inflammation

Publication details

Journal / source
Cell
Publisher
Elsevier BV
Volume
189
Issue
5
Pages
1356–1370.e26
Publication date
16 January 2026
Language
EN