Stochasticity in cancer immunotherapy stems from rare but functionally critical Spark T cells

Cell 2026

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Authors: Emanuel Salazar-Cavazos, Dongya Jia, Yoann Missolo-Koussou, Adam L Kenet, Sooraj R. Achar, Hannah Dada, Taisuke Kondo, Anagha Krishnan, Naomi Taylor, Nicholas D. Klemen, Peng Jiang, Joshua J. Waterfall
+2 more Don L. DeVoe, Grégoire Altan-Bonnet
DOI: 10.1016/j.cell.2025.12.026
Cited by: 3
References: 47

Fields of Study & Subjects

CAR-T cell therapy research Cancer Immunotherapy and Biomarkers Single-cell and spatial transcriptomics

Publication details

Journal / source
Cell
Publisher
Elsevier BV
Volume
189
Issue
4
Pages
1074–1085.e23
Publication date
1 February 2026
Language
EN