β-hydroxybutyrate enhances the metabolic fitness of CAR T cells in cancer

Cell 2026 Open access

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Authors: Shan Liu, Puneeth Guruprasad, Ranjani Ramasubramanian, Bhoomi Madhu, Luca Paruzzo, Kecheng Han, Andre Kelly, Alexander A. Shestov, He N. Xu, Alberto Carturan, Chaoting Zhou, Kevin R. Amses
+36 more Amichay Afriat, Lev Litichevskiy, Jason Lin, Ezra Dubowitz, Neil Tangal, Jing Zhang, Alana M. McSween, Melody T. Tan, Federico Stella, Andrew Lee, Siena Nason, Xianxin Hua, Michael Schneider, Madeleine Sleeman, Yunlin Zhang, Giulia Gabrielli, Ziqi Yang, Raymone Pajarillo, Ruchi Patel, Guido Ghilardi, Vrutti Patel, Akshita Joshi, Shunzhou Jiang, Yanqing Jiang, Patrizia Porazzi, Julia Tchou, Brian Keith, Ming Li, Elise A. Chong, Stephen J. Schuster, Michael C. Milone, Joshua Rabinowitz, Roddy S. O’Connor, Christoph A. Thaiss, Maayan Levy, Marco Antonio Ruella
DOI: 10.1016/j.cell.2026.02.004
Cited by: 14
References: 61

Fields of Study & Subjects

Cancer Hypoxia and Metabolism Diet and metabolism studies Forensic Toxicology and Drug Analysis

Publication details

Journal / source
Cell
Publisher
Elsevier BV
Volume
189
Issue
6
Pages
1701–1716.e24
Publication date
1 March 2026
Language
EN