GPAT4 regulates antitumor immune response through activating the mtDNA-cGAS axis in cancer cells

Cell Insight 2026 Open access

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Authors: Zi-Lun Ruan, Wei Liang, Yu-Tong Gong, Wen-Kai Guan, Xuan-Ang Zhou, Kai Jiang, Qing Yang, Ming‐Ming Hu
DOI: 10.1016/j.cellin.2026.100343
Cited by: 1
References: 54

Abstract

T cells and natural killer (NK) cells, which directly mediate tumor killing. In conclusion, our study identifies GPAT4 as a critical innate immune checkpoint molecule in tumor cells. Targeting this molecule can activate tumor-intrinsic innate immune pathways, thereby enhancing antitumor immune responses.

Fields of Study & Subjects

Peptidase Inhibition and Analysis Cholesterol and Lipid Metabolism Ubiquitin and proteasome pathways

Publication details

Journal / source
Cell Insight
Publisher
Elsevier BV
Volume
5
Issue
4
Pages
100343–100343
Publication date
18 June 2026
Language
EN