Decoding the epigenetics of persister states in ovarian cancer

Cell Reports 2026 Open access

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Authors: Anna Vähärautio, Anniina Färkkilä
DOI: 10.1016/j.celrep.2025.116754
Cited by: 0
References: 8

Abstract

Dumbrava et al. map a unified epigenetically primed persister state in high-grade serous ovarian carcinoma using single-nucleus multi-omics. Their work uncovers a chromatin-encoded tolerance program that precedes transcriptional change, revealing therapeutic options and motivating deeper spatiotemporal mapping of persister cells.

Fields of Study & Subjects

Genomics and Chromatin Dynamics Epigenetics and DNA Methylation Chromatin Remodeling and Cancer

Publication details

Journal / source
Cell Reports
Volume
45
Issue
1
Pages
116754–116754
Publication date
1 January 2026
Language
EN