GABAergic interneuron subtypes differentially regulate noise correlations that are critical for visual orientation discrimination in mice
Abstract
) neurons decreased them, reflecting their distinct inhibitory roles. These changes correlated with altered orientation-discrimination performance. Our linear regression model, integrating noise correlations with neuronal discriminability, successfully predicted individual animals' behavioral performance, demonstrating their synergistic influence on visual perception. These findings elucidate how inhibitory circuits regulate noise correlations and sensory processing, indicating potential therapeutic targets for sensory-processing disorders.
Fields of Study & Subjects
Visual perception and processing mechanisms
Neuroscience and Neuropharmacology Research
Neural dynamics and brain function
Publication details
- Journal / source
- Cell Reports
- Volume
- 45
- Issue
- 1
- Pages
- 116805–116805
- Publication date
- 1 January 2026
- Language
- EN