Insect salivary effectors disrupt PIEZO1-centric mechanoimmunity against piercing-sucking vectors

Cell Reports 2026 Open access

Read full text
Authors: Xiande Huang, Kaixing Gao, Pingzhi Zhao, Mengrong Wang, Qi Liu, Ran Li, Yanwei Sun, Zhijian Liang, Jian Ye
DOI: 10.1016/j.celrep.2025.116856
Cited by: 1
References: 72

Abstract

fluxes and SA/JA-mediated resistance to promote feeding. Notably, PIEZO1 represents a conserved target of salivary effectors from diverse piercing-sucking insect vectors across both plant and human hosts. Our study unveils the molecular mechanisms underlying host perception of and defense against piercing-sucking insects, pointing to novel strategies against both insects and insect-transmitted diseases.

Fields of Study & Subjects

Erythrocyte Function and Pathophysiology Neurobiology and Insect Physiology Research Toxin Mechanisms and Immunotoxins

Publication details

Journal / source
Cell Reports
Publisher
Elsevier BV
Volume
45
Issue
1
Pages
116856–116856
Publication date
1 January 2026
Language
EN