Hypoxia-inducible factor 1 protects neurons from Sarm1-mediated neurodegeneration

Cell Reports 2026 Open access

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Authors: Paul Meraner, A. A. Avetisyan, Kevin A. Swift, Ya-Chen Cheng, Romina Barría, Marc R. Freeman
DOI: 10.1016/j.celrep.2025.116873
Cited by: 1
References: 76

Abstract

loss driven by Sarm1 activation in neurons, despite NAD+ hydrolase activity being intrinsic to the Sarm1 TIR domain. Our work argues that hypoxia inhibits Sarm1 activity through HIF-1-driven transcriptional changes, rendering neurons in a hypoxic state less sensitive to Sarm1-mediated neurodegeneration.

Fields of Study & Subjects

Cancer Hypoxia and Metabolism Autophagy in Disease and Therapy Sirtuins and Resveratrol in Medicine

Publication details

Journal / source
Cell Reports
Publisher
Elsevier BV
Volume
45
Issue
2
Pages
116873–116873
Publication date
22 January 2026
Language
EN