Heterogeneity and plasticity of the naive CD4+ T cell compartment

Cell Reports 2026 Open access

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Authors: Alia Sajani, Evelien Schaafsma, Walburga Croteau, Mohamed ElTanbouly, Elizabeth C. Nowak, Chao Cheng, Christopher M. Burns, Mary Jo Turk, Randolph J. Noelle, J. Louise Lines
DOI: 10.1016/j.celrep.2026.116980
Cited by: 5
References: 56

Abstract

This study describes the transcriptional heterogeneity of murine and human naive CD4 + T cells as comprising multiple discrete clusters that impact CD4 + T cell fate and trajectories. Naive CD4 + T cells experiencing inflammatory environments exhibit an altered transcriptional state that biases their differentiation trajectories.

Fields of Study & Subjects

T-cell and B-cell Immunology Cancer Immunotherapy and Biomarkers Immune Cell Function and Interaction

Publication details

Journal / source
Cell Reports
Publisher
Elsevier BV
Volume
45
Issue
3
Pages
116980–116980
Publication date
18 February 2026
Language
EN