Spatiotemporal molecular profiling of macrophage-fibroblast crosstalk defines checkpoints orchestrating onset and resolution of inflammation

Cell Reports 2026 Open access

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Authors: Katharina Weishaupt, David Chambers, Maria Dzamukova, Ivana Androšević, Jean-Philippe Auger, Darleen Hueser, Sébastien Trzebanski, Andreas Ramming, Anika Grüneboom, Georg Schett, Steffen Jung, Markus H. Hoffmann
+1 more Gerhard Krönke
DOI: 10.1016/j.celrep.2026.117091
Cited by: 4
References: 43

Abstract

macrophages. These cells display a terminally differentiated phenotype, suppress the activation of pro-inflammatory SFs, and initiate the resolution of arthritis by secretion of regulatory mediators, including osteopontin. Our data highlight the dichotomous character of macrophage-fibroblast crosstalk and define the cellular and molecular checkpoints that control the onset and resolution of immune-mediated inflammatory diseases.

Fields of Study & Subjects

Immune cells in cancer Phagocytosis and Immune Regulation Cell Adhesion Molecules Research

Publication details

Journal / source
Cell Reports
Publisher
Elsevier BV
Volume
45
Issue
3
Pages
117091–117091
Publication date
1 March 2026
Language
EN