Integrin-dependent neutrophil slowing reduces lung perfusion and supports metastasis in a model of breast cancer

Cell Reports 2026 Open access

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Authors: Frédéric Fercoq, Gemma S. Cairns, Victoria L. Bridgeman, Marco De Donatis, John B. G. Mackey, Alessia Floerchinger, Amanda J. McFarlane, Judith Secklehner, Ximena L. Raffo-Iraolagoitia, Madeline Harrington, Lynn McGarry, Demi Brownlie
+13 more Declan Whyte, Lindsey W. G. Arnott, Colin Nixon, Robert Wiesheu, Anna Kilbey, Leah Brown, Sarwah Al-Khalidi, Jim C. Norman, Edward W. Roberts, Ilaria Malanchi, Karen Blyth, Seth B. Coffelt, Leo M. Carlin
DOI: 10.1016/j.celrep.2026.117101
Cited by: 2
References: 47

Abstract

integrins. Overall, our study proposes that integrin-mediated neutrophil congestion of the alveolar capillaries contributes to the pulmonary pre-metastatic niche.

Fields of Study & Subjects

Cell Adhesion Molecules Research Neutrophil Myeloperoxidase and Oxidative Mechanisms Immune cells in cancer

Publication details

Journal / source
Cell Reports
Publisher
Elsevier BV
Volume
45
Issue
3
Pages
117101–117101
Publication date
1 March 2026
Language
EN