Antibacterial microcins self-assemble to promote biofilm formation in Acinetobacter baumannii

Cell Reports 2026 Open access

Read full text
Authors: Mady S. Telford, Michelle Mikesh, Jennifer K. Parker, Robert L. Beckman, Robert W. Newberry, Renee M. Fleeman, Bryan W. Davies
DOI: 10.1016/j.celrep.2026.117156
Cited by: 2
References: 81

Abstract

The bacterial pathogen Acinetobacter baumannii forms a resilient biofilm, enhancing bacterial survival in hostile environments. Although biofilm structure is primarily built from polysaccharides and nucleic acids, specific proteins are often essential for its development and integrity. Here, we identify microcins as a driver of biofilm formation in A. baumannii. Microcins are small (

Fields of Study & Subjects

Bacterial biofilms and quorum sensing Antibiotic Resistance in Bacteria Microbial Natural Products and Biosynthesis

Publication details

Journal / source
Cell Reports
Publisher
Elsevier BV
Volume
45
Issue
4
Pages
117156–117156
Publication date
25 March 2026
Language
EN