Microglial clonal dynamics and the impact of clonal hematopoiesis in autologously transplanted rhesus macaques

Cell Reports 2026 Open access

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Authors: Yifan Zhou, Diana M. Abraham, Rohan V. Hosuru, Taha Bartu Hayal, Ashley Gin, Xing Fan, Byung-Chul Lee, Taehoon Shin, E. Lake Potter, So Gun Hong, Mario Roederer, George S. Vassiliou
+2 more Chuanfeng Wu, Cynthia E. Dunbar
DOI: 10.1016/j.celrep.2026.117561
Cited by: 1
References: 64

Abstract

Microglia are central nervous system (CNS)-resident macrophages, with key roles in immune surveillance, phagocytosis, and synaptic pruning. Yolk sac-derived microglia show minimal turnover from hematopoietic stem/progenitor cells (HSPCs) under steady-state conditions in mice. However, clinical benefits observed in patients receiving HSPC gene therapies for CNS disorders suggest functional integration of HSPC-derived cells. To investigate microglia replacement and the impact of clonal hematopoiesis (CH) on microglia, we analyzed microglia in rhesus macaques receiving barcoded or CRISPR-edited (TET2-mutant) HSPC transplants. We found that

Fields of Study & Subjects

Neuroinflammation and Neurodegeneration Mechanisms Immunotoxicology and immune responses Multiple Sclerosis Research Studies

Publication details

Journal / source
Cell Reports
Publisher
Elsevier BV
Volume
45
Issue
7
Pages
117561–117561
Publication date
19 June 2026
Language
EN