Systematic cysteine scanning identifies a druggable pocket in oncogenic KRAS

Cell chemical biology 2026

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Authors: Laurens M. van Tienen, Shadwa Bayoumi, Khaja Muneeruddin, Nancy Leymarie, Alexandra Popa, Mrinal Shekhar, Madeline A. Mueller, Ruitong Li, Krzysztof M. Żak, Harsha Chilukuri, David J. P. Kornfilt, Thomas C. Atack
+10 more Devishi Kesar, Yuemin Bian, Katharin L. Shaw, Zuzana Jandova, Philipp Trollmann, Leonhard Geist, Peggy Stolt-Bergner, Klaus Rumpel, Dirk Kessler, William R. Sellers
DOI: 10.1016/j.chembiol.2026.01.007
Cited by: 1
References: 51

Fields of Study & Subjects

Chemical Synthesis and Analysis Biochemical and Structural Characterization Click Chemistry and Applications

Publication details

Journal / source
Cell chemical biology
Publisher
Elsevier BV
Volume
33
Issue
2
Pages
241–255.e8
Publication date
1 February 2026
Language
EN