Solutions reproducibility in multiresponse optimization problems: A new desirability-based objective function

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Authors: Nuno Costa, João Carlos Lourenço
Cited by: 2
References: 85

Abstract

Theoretical solutions for multiresponse problems may not yield the expected results when implemented in practice at the process and/or product level. Causes that have been overlooked and lead to such discrepancies in problems developed under the Response Surface Methodology framework are the magnitude of prediction errors in some regions of the solution space, unreplicated experimental runs, and responses’ sensitivity to changes in the values of response model variables. That discrepancy value must be minimized and can be managed in the generation of optimal solutions. Therefore, to improve the reproducibility of theoretical solutions, a new desirability-based function is proposed. This objective function allows to balance the response’s bias, predictions quality, robustness, and resilience according to the decision maker’s preferences. Two case studies demonstrate its flexibility and usefulness.

Fields of Study & Subjects

Process Optimization and Integration Advanced Optimization Algorithms Research Optimization and Variational Analysis

Publication details

Journal / source
Chemometrics and Intelligent Laboratory Systems
Publisher
Elsevier BV
Volume
271
Pages
105650–105650
Publication date
28 January 2026
Language
EN