A haplotype-resolved genome assembly for Centella asiatica provides insights into its genome evolution and ursane-type triterpene accumulation

The Crop Journal 2026 Open access

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Authors: Chao Wang, Yingchen Hao, Zhonghui Zhang, Xumin Ou, Zifei Guo, Shouchuang Wang, Jun Yang
DOI: 10.1016/j.cj.2026.02.003
Cited by: 1
References: 66

Abstract

Centella asiatica is a medicinal plant containing various ursane-type saponins that serve as a model system for studying triterpenoid accumulation. We assembled a haplotype-resolved genome for C. asiatica , and it showed allelic imbalance between haplotypes. The genome underwent one whole-genome duplication event followed by chromosomal fusion resulting in the current karyotype. We also constructed the metabolic regulatory network of triterpenoid saponins and found that triterpenoid biosynthesis was accompanied by gene duplication. These findings may assist in mining genes for the metabolism of C. asiatica and improving the understanding of the genetic basis for the diversity of triterpenoid biosynthesis

Fields of Study & Subjects

Medicinal Plants and Neuroprotection Biological Stains and Phytochemicals Cassava research and cyanide

Publication details

Journal / source
The Crop Journal
Publisher
Elsevier BV
Volume
14
Issue
3
Pages
959–971
Publication date
27 February 2026
Language
EN