Eosinophilic Myocarditis With Eosinophil Extracellular Traps and Charcot-Leyden Crystals

Canadian Journal of Cardiology 2026 Open access

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Authors: Sho Hirayama, Tomoe Abe, Takeshi Kashimura, Freja Friis Lajer, Shigeharu Ueki, Hajime Umezu, Soma Sato, Kazuyo Tanaka, Yuka Sekiya, Hiroki Tsuchiya, Takayuki Kumaki, Ryohei Sakai
+4 more Hiromi Kayamori, Shinya Fujiki, Tsugumi Takayama, Takayuki Inomata
DOI: 10.1016/j.cjca.2026.01.015
Cited by: 0
References: 5

Abstract

Eosinophil extracellular traps (EETs) are a host defense mechanism in which net-like DNA structures and intracellular toxic granules are released to capture and damage pathogens.1 EETosis, the programmed cell death process associated with EET formation, has been implicated in various eosinophilic disorders.2 In eosinophilic myocarditis (EM), released eosinophil granules damage cardiomyocytes2; however, the mechanism of the release remains unexplored. Here, we describe the first case demonstrating EETosis in EM confirmed by both immunofluorescence (IF) and transmission electron microscopy (TEM).

Fields of Study & Subjects

Eosinophilic Disorders and Syndromes Viral Infections and Immunology Research Neutrophil Myeloperoxidase and Oxidative Mechanisms

Publication details

Journal / source
Canadian Journal of Cardiology
Volume
42
Issue
8
Pages
1919–1922
Publication date
17 January 2026
Language
EN