Trends and contemporary epidemiology of mortality with primary immunodeficiency diseases in the United States, 2015–2022
Abstract
There is paucity of data on recent trends of population-level deaths with Primary Immunodeficiency Diseases (PIDD). To examine the population-based temporal trends in deaths with PIDD in the United States from 2015 to 2022. We performed a retrospective, serial cross-sectional analysis of national death certificate data from 2015 through 2022. We evaluated the changes in the PIDD age-adjusted mortality rate per 1,000,000 (AAMR), overall, then stratified by age, gender, and race/ethnicity. The overall AAMR increased significantly from 2.5 to 3.5 (P
Fields of Study & Subjects
Immunodeficiency and Autoimmune Disorders
T-cell and B-cell Immunology
Immune responses and vaccinations
Publication details
- Journal / source
- Clinical Immunology Communications
- Volume
- 9
- Pages
- 54–58
- Publication date
- 18 January 2026
- Language
- EN