Optimal delivery of enteral protein in the critically ill: A systematic review and meta-analysis of randomised controlled trials

Clinical Nutrition 2026 Open access

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Authors: Matthew J. Summers, Julia L.M. Bels, Amalia Karahalios, Rukshala K. Gunaratne, Jeffrey Presneill, Mark P. Plummer, Zheng‐Yii Lee, Daren K. Heyland, Dieter Mesotten, Christian Stoppe, Marcel C.G. van de Poll, Sandra Peake
+2 more Adam M. Deane, Lee‐anne S. Chapple
DOI: 10.1016/j.clnu.2026.106665
Cited by: 4
References: 46

Abstract

BACKGROUND AND AIM: Critically ill patients experience acute muscle wasting, associated with impaired clinical outcomes. It has been suggested that greater dietary protein delivery may attenuate muscle wasting and improve outcomes, but the optimal dose is unknown. The aim of this systematic review and meta-analysis was to evaluate the effect of enteral protein delivered to achieve doses recommended within international guidelines (1.2-2.0 g/kg bodyweight/day) compared to enteral protein delivered below international guidelines (

Fields of Study & Subjects

Clinical Nutrition and Gastroenterology Infant Nutrition and Health Enhanced Recovery After Surgery

Publication details

Journal / source
Clinical Nutrition
Publisher
Elsevier BV
Volume
61
Pages
106665–106665
Publication date
16 April 2026
Language
EN