Dual targeting of SLC25A51 and succinate dehydrogenase selectively depletes mitochondrial NAD+ to eradicate KRAS-driven AML

Cell Metabolism 2026

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Authors: Ang Jia, Xiaowen Zhang, Jihao Zhou, Yongcan Ma, Jing Wang, Yongbo Gong, Wenjie Song, Hangcheng Hu, Yufei Yu, Haixia Yang, Youli Lu, Linzhang Huang
+7 more Xingrong Du, Chunmei Chang, Shanshan Pei, Peng Li, Craig T. Jordan, Tong‐Jin Zhao, Haobin Ye
DOI: 10.1016/j.cmet.2026.01.001
Cited by: 2
References: 55

Fields of Study & Subjects

Acute Myeloid Leukemia Research Cancer Hypoxia and Metabolism Immune cells in cancer

Publication details

Journal / source
Cell Metabolism
Publisher
Elsevier BV
Volume
38
Issue
6
Pages
1113–1129.e12
Publication date
29 January 2026
Language
EN