Lack of PCK1 in hepatic stellate cells causes liver fibrosis by fueling tricarboxylic acid cycle and increasing glycolysis

Cell Metabolism 2026

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Authors: Eva Nóvoa, Tamara Parracho, Julica Inderhees, Amaia Rodriguez, Cristina Riobello, Jose Iglesias-Moure, Anabel Fernández-Iglesias, Sara Martinez-Martinez, Ana Senra, Samuel Seoane, Marcos F. Fondevila, Cristina Iglesias
+22 more Alba Cabaleiro, Natalia da Silva Lima, Valentina Dorta, Borja López-Picallo, Lucia Ramos-Lage, Ashwin Woodhoo, Miguel Álvarez Fidalgo, Maria L. Martinez‐Chantar, Francisco Javier Cubero, Miguel López, Carlos Diéguez, Diana Guallar, Vincent Prévot, Robert F. Schwabe, Gema Frühbeck, Javier Crespo, Marta Varela-Rey, María J. Gonzalez-Rellan, Jordi Gracia‐Sancho, Paula Iruzubieta, Markus Schwaninger, Ruben Nogueiras
DOI: 10.1016/j.cmet.2026.01.016
Cited by: 4
References: 37

Fields of Study & Subjects

Liver physiology and pathology Liver Disease Diagnosis and Treatment Liver Diseases and Immunity

Publication details

Journal / source
Cell Metabolism
Publisher
Elsevier BV
Volume
38
Issue
4
Pages
729–745.e9
Publication date
23 February 2026
Language
EN