How personality functioning shapes symptom development during and after treatment: A random intercept cross lagged panel analysis

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Authors: Jürgen Fuchshuber, Henrik Kessler, Aram Kehyayan, Magdalena Pape, Tobias Hofmann, Matthias Rose, Katrin Imbierowicz, Franziska Geiser, Ilona Croy, Kerstin Weidner, Jörg Rademacher, Silke Michalek
+30 more Eva Morawa, Yeşim Erim, Martin Teufel, Alexander Bäuerle, Stanislav Heinzmann, Claas Lahmann, Eva Milena Johanne Peters, Johannes Kruse, Dirk von Boetticher, Christoph Herrmann-Lingen, Mariel Nöhre, Martina de Zwaan, Ulrike Dinger, Hans-Christoph Friederich, Alexander Niecke, Christian Albus, Rüdiger Zwerenz, Manfred Beutel, Casper Roenneberg, Peter Henningsen, Barbara Stein, Christiane Waller, Karsten Hake, Carsten Spitzer, Andreas Stengel, Stephan Zipfel, Katja Weimer, Harald Gündel, Stephan Herpertz, Stephan Doering
Cited by: 1
References: 54

Abstract

OBJECTIVES: This study investigates the long-term influence of fluctuations around the individual's means of personality functioning (PF) on mental and physical symptoms in a large sample of patients receiving psychotherapy. METHODS: We reanalyzed observational data of 2094 participants (68% female; age M = 39.89 years; SD = 14.20 years) which took part in the Multicenter Effectiveness Study of Inpatient Psychosomatic Psychotherapeutic Treatment (short: MEPP) at three time points. A Random Intercept-Cross Lagged Panel Model (RI-CLPM) was used to examine within-person longitudinal effects between PF (OPD-SQS) and depressive symptoms (PHQ-9), anxiety (GAD-7) and somatic symptom load (PHQ-15). The model was controlled for age, sex, treatment condition and treatment length. RESULTS: Strong between-person intercorrelations were observed between all investigated constructs. At the longitudinal within-person level PF at hospital discharge predicted somatic symptom load (p < .01), depressive symptoms, anxiety and itself (all p < .05) at follow up, however, PF showed no effect during treatment (p > .05). Furthermore, depressive symptoms at baseline influenced general symptom burden and PF development during treatment (all p < .05) and showed strong effects on anxiety and somatic symptoms at follow up (p < .001). CONCLUSIONS: The results suggest a sustained influence of intraindividual PF deviations on general symptom development after psychotherapy, but also emphasize the effect of depressive symptoms in psychotherapy outcomes.

Fields of Study & Subjects

Personality Disorders and Psychopathology Personality Traits and Psychology Psychological Testing and Assessment

Publication details

Journal / source
Comprehensive Psychiatry
Publisher
Elsevier BV
Volume
148
Pages
152712–152712
Publication date
12 May 2026
Language
EN