Expanding the catalytic repertoire of C–C bond–forming pyridoxal 5′-phosphate-dependent enzymes for noncanonical amino acid formation
Abstract
Noncanonical amino acids (ncAAs) are pharmaceutically important molecules with diverse biological and chemical applications. Among various production strategies, biocatalytic synthesis using pyridoxal 5'-phosphate (PLP)-dependent enzymes has attracted considerable attention owing to their high stereoselectivity and versatility in forming new C-C bonds. Recent advances in enzyme engineering have further expanded the catalytic potential of PLP-dependent enzymes, enabling the tailored synthesis of target ncAAs. In this short review, we summarize recent developments in biocatalytic ncAA synthesis achieved through engineered PLP-dependent enzymes.
Fields of Study & Subjects
Enzyme Catalysis and Immobilization
Enzyme Structure and Function
Carbohydrate Chemistry and Synthesis
Publication details
- Journal / source
- Current Opinion in Biotechnology
- Publisher
- Elsevier BV
- Volume
- 97
- Pages
- 103437–103437
- Publication date
- 21 January 2026
- Language
- EN