The role of aminopeptidases in angiotensin peptide processing
Abstract
Plasma and tissue levels of angiotensin peptides are regulated by their formation and metabolism by peptidases. Aminopeptidases A and N process Ang II to Ang III and Ang III to Ang IV respectively, peptides which may have the same physiological action as, or counterbalance the action of, Ang II. In this minireview, other pathways for the processing of both Ang I and Ang II by aminopeptidases will be outlined. Further, differential processing of Ang I and Ang II by different cell types comprising the renal glomerulus will be discussed. Importantly, by playing a role in the regulation of Ang II levels, both systemically and intra-renally, aminopeptidase A acts to tonically control blood pressure, and to moderate Ang II-induced renal injury.
Fields of Study & Subjects
Protein Hydrolysis and Bioactive Peptides
Renin-Angiotensin System Studies
Neuropeptides and Animal Physiology
Publication details
- Journal / source
- Current Opinion in Physiology
- Publisher
- Elsevier BV
- Volume
- 47
- Pages
- 100898–100898
- Publication date
- 9 January 2026
- Language
- EN