An integrated single-cell and spatial proteotranscriptomics atlas of fibroblast-driven immunoregulation within the human adult oral cavity

Cell Press Blue 2026 Open access

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Authors: Bruno F. Matuck, Khoa L.A. Huynh, Diana Pereira, Quinn T. Easter, XiuYu Zhang, Meik Kunz, Nikhil M Kumar, Aditya Pratapa, Brittany T. Rupp, Ameer Ghodke, Alexander V. Predeus, Alexandre Moreira Fernandes
+19 more Lili Szabó, Stefan Hartmann, Nadja Harnischfeger, Zohreh Khavandgar, Margaret Beach, Paola Perez, Benedikt S. Nilges, María Marcianes Moreno, Kang I. Ko, Rohit Kumar Singh, Purushothama Rao Tata, Sarah A. Teichmann, Adam J. Kimple, Sarah Pringle, Kai Kretzschmar, Blake M. Warner, Inês Sequeira, Jinze Liu, Kevin M. Byrd
DOI: 10.1016/j.cpblue.2026.100007
Cited by: 5
References: 59

Abstract

fibroblasts and predicted spatial engagement with T cells at tertiary lymphoid structures. Together, this atlas identifies fibroblasts as central regulators of structural immunity and provides a scalable framework to target stromal-immune interactions across barrier organs.

Fields of Study & Subjects

Single-cell and spatial transcriptomics Oral Health Pathology and Treatment Bone and Dental Protein Studies

Publication details

Journal / source
Cell Press Blue
Publisher
Elsevier BV
Volume
1
Issue
1
Pages
100007–100007
Publication date
23 March 2026
Language
EN