Integrin α3 (ITGA3) expression across breast cancer subtypes: Prognosis and therapeutic relevance

Cancer Pathogenesis and Therapy 2026 Open access

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Authors: Weijie Ma, Hongyuan Zhao, Reggie R. Fan, Chihong Zhou, Dingning Liu, Shuai A. Chen, Tianhong Li
DOI: 10.1016/j.cpt.2026.01.004
Cited by: 2
References: 38

Abstract

Background: expression across breast cancer molecular subtypes and assessed its prognostic and predictive significance. Methods: mRNA expression, co-expressed signaling pathways, and associations with therapeutic response. Results: expression was not predictive of response to tamoxifen or trastuzumab. Conclusion: expression is associated with breast cancer recurrence and poor clinical outcomes, supporting its potential role as a prognostic biomarker and candidate therapeutic target.

Fields of Study & Subjects

Cell Adhesion Molecules Research TGF-β signaling in diseases Cellular Mechanics and Interactions

Publication details

Journal / source
Cancer Pathogenesis and Therapy
Publisher
Elsevier BV
Volume
4
Issue
5
Pages
412–420
Publication date
4 February 2026
Language
EN