α-Amino acid; (±)-aspartic acid catalyzed green synthesis of 2-amino-7-hydroxy-4-aryl-4H-chromene-3-carbonitrile derivatives in aqueous medium

We have created a sustainable process for the green, efficient, and straightforward synthesis of 2-amino-7-hydroxy-4-aryl-4 H -chromene-3-carbonitrile derivatives. A domino Knoevenagel-Michael cyclocondensation reaction is used in the procedure. A green, inexpensive, and efficient organocatalyst, α-amino acid; (±)-aspartic acid, is used to catalyze the reaction at reflux in an aqueous medium. Principles of sustainable chemistry are applied in this process. Reactions occur more quickly, producing very good to high yields. It doesn't use the chromatographic method to separate mixtures. This is a cheap and simple method. It is quick and convenient because it combines several steps into one-pot. • α-Amino acid; (±)-aspartic acid as catalyst • Aqueous medium • Green synthesis of 2-amino-7-hydroxy-4-aryl-4 H -chromene-3-carbonitrile derivatives