Disinhibition of cerebellar output by loss of restless legs syndrome-associated gene MEIS1
Abstract
Genome-wide association studies have identified risk variants for restless legs syndrome (RLS), 1 , 2 , 3 , 4 , 5 , 6 but the behavioral functions and sites of action of the corresponding genes remain unknown. Here, we analyzed zebrafish mutants for candidate RLS genes and found that meis1b is required for normal locomotion behavior and cerebellar development. Neuronal manipulation experiments indicated that loss of meis1b perturbs locomotor behavior by generating abnormal cerebellar output—a mechanism reminiscent of movement disorders such as ataxia and dystonia.
Fields of Study & Subjects
Restless Legs Syndrome Research
Neurological disorders and treatments
Parkinson's Disease Mechanisms and Treatments
Publication details
- Journal / source
- Current Biology
- Publisher
- Elsevier BV
- Volume
- 36
- Issue
- 13
- Pages
- 3380–3387.e3
- Publication date
- 17 June 2026
- Language
- EN